However, to avoid side effects, if you are using it on your face or neck, you should use it for the least amount of time possible. Hydrocortisone can be used for up to 3 months. Hydrocortisone cream should not be used as a first-line treatment for pimples, nor should it be used in concentrations higher than 2.5% without your dermatologist’s supervision. You can apply hydrocortisone cream once or twice daily. If you are using it for multiple days, apply it around the same time every day.
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